ketamine, mdma, mescaline, lsd, psilocybin molecules

Comparing Psychedelic Drugs for Therapy: Legality, Efficacy & Safety

Psychedelic therapy for anxiety and depression is a hot topic these days. You may have heard about it on Michael Pollan’s recent Netflix series, How to Change Your Mind. The series devotes each episode to a different psychedelic medicine including LSD, psilocybin, MDMA and mescaline. These four drugs all have their own benefits and drawbacks, similarly to ketamine. Let’s take a look at each drug’s legal status, safety concerns and indicated uses.

hand holding s ketamine molecule next to hand holding r ketamine molecule

S-Ketamine vs. R-Ketamine

In early 2019, an esketamine nasal spray was approved by the FDA for adults with treatment-resistant depression. Its FDA-approved uses were later expanded to include patients suffering from acute suicidal ideation. But what is esketamine, and how is it different from regular ketamine?