Psychedelic therapy for anxiety and depression is a hot topic these days. You may have heard about it on Michael Pollan’s recent Netflix series, How to Change Your Mind. The series devotes each episode to a different psychedelic medicine including LSD, psilocybin, MDMA and mescaline. These four drugs all have their own benefits and drawbacks, similarly to ketamine. Let’s take a look at each drug’s legal status, safety concerns and indicated uses.