Microdosing is a common term that has become a part of the cultural vernacular. It is the practice of ingesting a very low dose of a psychedelic substance. A microdose is small enough that it does not impair “normal” functioning, but still has an effect. This is unlike macrodoses used in recreation or in psychedelic therapy.
Microdose doesn’t yet have an agreed upon scientific definition. Researchers typically use the term for one-fifth to one-twentieth of a recreational dose. Two microdose studies of pure psilocin (the active ingredient in psychedelic mushrooms) considered a microdose to be less than 1 milligram. This is compared to a 15 milligram “medium dose” as defined in those studies.
- Microdosing can make the user more creative, insightful, and even more alert. For example, microdoses of LSD stretch out perception of time. Tiny doses can affect brain activity even when too small for the user to feel any subjective changes.
- Microdosing can improve mood by changing serotonin regulation.
- Microdosing can help with pain. It has been known to alleviate migraines and menstrual cramps.
Microdose vs. Macrodose
A macrodose is often about 150% or more of a standard dose. For example, if 3.5 grams is a standard dose of magic mushrooms, the macrodose or “heroic dose” is 5 grams or more, as advocated by psychedelic researcher, Terence McKenna.
With microdosing, the sense of self remains very much intact. It adjusts the user’s everyday experience, but does not plunge them into a highly altered state.
There are self-reported studies of microdosing with LSD, psilocybin, ketamine, and DMT, but there are only a few controlled studies. Ketamine microdose research is still in animal stages. The most rigorous study of LSD microdosing found the effects were small – and could be mostly attributed to the positive placebo effect.
Is Microdosing For You?
Currently in the United States, there are no legal protocols outside academic studies that prescribe microdoses of psychedelics. If you are in a country where psychedelics are legal or certain states where psychedelics are decriminalized, the question of whether to microdose is a question of risk acceptance.
On the other hand, there is widespread anecdotal evidence that microdosing can improve mood and attention. The scientific evidence to date is only preliminary. The larger doses used in psychedelic therapy have better known effects. Microdosing remains mostly a mystery.
If you are considering microdosing, it might be worthwhile to read James Fadiman’s “The Psychedelic Explorer’s Guide”. Or Ayelett Waldman’s “A Really Good Day”.
Disclaimer: Nushama only offers legal ketamine services and many of the substances mentioned are in various states of legalization, decriminalization, and scientific study.